Job Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at  . Follow @abbvie on  X ,  Facebook ,  Instagram ,  YouTube ,  LinkedIn and  Tik Tok .

Job Description

Job Description

AbbVie is looking for a talented scientist with strong expertise in protein NMR spectroscopy to join our Lake County, Illinois, Biophysics team. This scientist, using NMR spectroscopy and computational methods will play a central role in the discovery and advancement of small molecule-based therapeutics across a variety of disease areas. As an integral member of our team, you will drive projects and collaborate across various functions within our Discovery organization. The ideal candidate should have extensive hands-on experience with high-resolution NMR spectroscopy including design, set-up, troubleshooting, and interpretation of 1D, 2D, and 3D experiments along with solid understanding of spectrometer hardware. Experience with NMR-based fragment screening, including protein sample optimization, collection of 1D and 2D NMR screening data, and use of ligand-induced chemical shift perturbations and protein-ligand NOE data to dock fragments into protein binding sites would be a plus. Success in this position will require both strong collaborative skills and excellent communication skills. 

Key Responsibilities:

• Design and implement NMR experiments (1D and 2D) for evaluation of ligand binding to protein targets and for fragment screening of protein targets
• Set-up NMR spectrometer for the collection of protein-ligand NOE data to enable ligand docking
• Process and analyze NMR screening data and structural NOE data
• Employ computational methods for CSP/NOE-guided docking of ligands into protein binding sites
• Set-up and troubleshoot 1D, 2D, and 3D experiments taken from the literature
• Prepare protein samples for NMR-based studies, including buffer optimization
• Work with AbbVie personnel and vendors, when necessary, to maintain and repair spectrometers
• Maintain accurate and timely records of experimental results
• Interact with other members of the Biophysics Drug Discovery team to evaluate where NMR methods can be most effectively employed
• Present results at internal meetings
• Present results at external scientific meetings as appropriate
• Publish experimental results in peer-reviewed journals as appropriate
• Work closely with project teams to identify and solve key questions within the domain of small molecule drug discovery

Qualifications

Education/Experience:

Job grade, level, and title will be determined by the selected candidate’s credentials, education, and experience.

• PhD in Chemistry, Biochemistry, Biophysics, or a related field
• At least 2 years of relevant academic or industry experience is required
• Extensive experience in high-resolution NMR spectroscopy, including design, set-up, troubleshooting, and interpretation of 1D, 2D, and 3D experiments
• Scripting languages and pulse sequence programing ability would be a plus
• Must be detail oriented and meticulous regarding documentation and data management
• Ability to work both independently and as part of a highly collaborative, interdisciplinary team
• Effective written and verbal communication skills
• Ability to work on multiple projects in parallel and rapidly adjust to changing priorities

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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